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A proposed mechanism by which statins may influence macrophage accumulation is by reducing expression of histone mRNA, a marker of cell proliferation, on macrophages as determined by an in vivo rabbit study using cerivastatin (0.6 mg/kg/day) (Aikawa et al., 2001)

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PMID: 211 SchnupfPGaboriau-RouthiauVSansonettiPJCerf-BensussanN

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Another rodent study conducted by Rossi et al reported no significant differences in TFR between control rats and rats exposed to JP-5 or JP-6 after a 65-day recovery period